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Exported proteins required for virulence and rigidity of Plasmodium falciparum-infected human erythrocytes.

Abstract:

A major part of virulence for Plasmodium falciparum malaria infection, the most lethal parasitic disease of humans, results from increased rigidity and adhesiveness of infected host red cells. These changes are caused by parasite proteins exported to the erythrocyte using novel trafficking machinery assembled in the host cell. To understand these unique modifications, we used a large-scale gene knockout strategy combined with functional screens to identify proteins exported into parasite-infe...

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Publication status:
Published

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Publisher copy:
10.1016/j.cell.2008.04.051

Authors


O'Neill, MT More by this author
Chakravorty, S More by this author
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Journal:
Cell
Volume:
134
Issue:
1
Pages:
48-61
Publication date:
2008-07-05
DOI:
EISSN:
1097-4172
ISSN:
0092-8674
URN:
uuid:9c9e1233-a616-40fc-bda6-343afabc8ff0
Source identifiers:
94903
Local pid:
pubs:94903

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