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Effector and memory CD8+ T cells can be generated in response to alloantigen independently of CD4+ T cell help.

Abstract:

There is now considerable evidence suggesting that CD8(+) T cells are able to generate effector but not functional memory T cells following pathogenic infections in the absence of CD4(+) T cells. We show that following transplantation of allogeneic skin, in the absence of CD4(+) T cells, CD8(+) T cells become activated, proliferate, and expand exclusively in the draining lymph nodes and are able to infiltrate and reject skin allografts. CD44(+)CD8(+) T cells isolated 100 days after transplant...

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Publication status:
Published

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Publisher copy:
10.4049/jimmunol.176.4.2316

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Journal:
Journal of immunology (Baltimore, Md. : 1950)
Volume:
176
Issue:
4
Pages:
2316-2323
Publication date:
2006-02-05
DOI:
EISSN:
1550-6606
ISSN:
0022-1767
URN:
uuid:9c9d7426-c7ab-4e98-be49-516f424d1856
Source identifiers:
135963
Local pid:
pubs:135963

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