- Abstract:
-
There is now considerable evidence suggesting that CD8(+) T cells are able to generate effector but not functional memory T cells following pathogenic infections in the absence of CD4(+) T cells. We show that following transplantation of allogeneic skin, in the absence of CD4(+) T cells, CD8(+) T cells become activated, proliferate, and expand exclusively in the draining lymph nodes and are able to infiltrate and reject skin allografts. CD44(+)CD8(+) T cells isolated 100 days after transplant...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.4049/jimmunol.176.4.2316
-
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- Journal:
- Journal of immunology (Baltimore, Md. : 1950)
- Volume:
- 176
- Issue:
- 4
- Pages:
- 2316-2323
- Publication date:
- 2006-02-05
- DOI:
- EISSN:
-
1550-6606
- ISSN:
-
0022-1767
- URN:
-
uuid:9c9d7426-c7ab-4e98-be49-516f424d1856
- Source identifiers:
-
135963
- Local pid:
- pubs:135963
- Copyright date:
- 2006
Journal article
Effector and memory CD8+ T cells can be generated in response to alloantigen independently of CD4+ T cell help.
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