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Oxygen-tolerant [NiFe]-hydrogenases: the individual and collective importance of supernumerary cysteines at the proximal Fe-S cluster.

Abstract:

An important clue to the mechanism for O(2) tolerance of certain [NiFe]-hydrogenases is the conserved presence of a modified environment around the iron-sulfur cluster that is proximal to the active site. The O(2)-tolerant enzymes contain two cysteines, located at opposite ends of this cluster, which are glycines in their O(2)-sensitive counterparts. The strong correlation highlights special importance for electron-transfer activity in the protection mechanism used to combat O(2). Site-direct...

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Publication status:
Published

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Publisher copy:
10.1021/ja205393w

Authors


Roessler, MM More by this author
Davies, RA More by this author
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Journal:
Journal of the American Chemical Society
Volume:
133
Issue:
42
Pages:
16881-16892
Publication date:
2011-10-05
DOI:
EISSN:
1520-5126
ISSN:
0002-7863
URN:
uuid:9c8fa92d-13fa-4e41-a8f7-b57bc8df0a90
Source identifiers:
186561
Local pid:
pubs:186561

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