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Glycosphingolipid synthesis requires FAPP2 transfer of glucosylceramide.

Abstract:

The molecular machinery responsible for the generation of transport carriers moving from the Golgi complex to the plasma membrane relies on a tight interplay between proteins and lipids. Among the lipid-binding proteins of this machinery, we previously identified the four-phosphate adaptor protein FAPP2, the pleckstrin homology domain of which binds phosphatidylinositol 4-phosphate and the small GTPase ARF1. FAPP2 also possesses a glycolipid-transfer-protein homology domain. Here we show that...

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Publication status:
Published

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Publisher copy:
10.1038/nature06097

Authors


D'Angelo, G More by this author
Polishchuk, E More by this author
Di Tullio, G More by this author
Santoro, M More by this author
Di Campli, A More by this author
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Journal:
Nature
Volume:
449
Issue:
7158
Pages:
62-67
Publication date:
2007-09-05
DOI:
EISSN:
1476-4687
ISSN:
0028-0836
URN:
uuid:9c8b4ab1-5f60-4fba-89ff-57d8148c21e4
Source identifiers:
185127
Local pid:
pubs:185127

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