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Journal article

Mouse genomic variation and its effect on phenotypes and gene regulation.

Abstract:

We report genome sequences of 17 inbred strains of laboratory mice and identify almost ten times more variants than previously known. We use these genomes to explore the phylogenetic history of the laboratory mouse and to examine the functional consequences of allele-specific variation on transcript abundance, revealing that at least 12% of transcripts show a significant tissue-specific expression bias. By identifying candidate functional variants at 718 quantitative trait loci we show that t...

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Publication status:
Published online

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Publisher copy:
10.1038/nature10413

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Journal:
Nature
Volume:
477
Issue:
7364
Pages:
289-294
Publication date:
2011-09-14
DOI:
EISSN:
1476-4687
ISSN:
0028-0836
URN:
uuid:9c87ae43-1a12-4405-b2c2-bcd5665db747
Source identifiers:
177351
Local pid:
pubs:177351

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