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Thesis

Combining digital histology with magnetic resonance imaging in amyotrophic lateral sclerosis

Abstract:

There is an increasing demand for non-invasive biomarkers that can reliably indicate the presence and extent of neurodegeneration in its early stages. Various magnetic resonance imaging (MRI) methods have shown great potential to indicate the event of upper motor neuron involvement in the progression of amyotrophic lateral sclerosis (ALS) at the population level, but almost none of these have been systematically validated against traditional histological markers at the individual level. Va...

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Authors

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Institution:
University of Oxford
Division:
MSD
Department:
Clinical Neurosciences
Sub department:
Clinical Neurosciences
Research group:
Wellcome Centre for Integrative Neuroimaging
Oxford college:
Kellogg College
Role:
Author
ORCID:
0000-0002-4079-9465

Contributors

Role:
Supervisor
Role:
Supervisor
Role:
Supervisor
ORCID:
0000-0001-7912-2251
More from this funder
Funder identifier:
http://dx.doi.org/10.13039/100010269
Grant:
203139/Z/16/Z
Programme:
Core funding for the Wellcome Centre for Integrative Neuroimaging
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Funder identifier:
http://dx.doi.org/10.13039/501100000265
Grant:
EP/L016052/1
Programme:
EPSRC & MRC Centre for Doctoral Training in Biomedical Imaging
More from this funder
Funder identifier:
http://dx.doi.org/10.13039/501100000266
Grant:
EP/L016052/1
Programme:
EPSRC & MRC Centre for Doctoral Training in Biomedical Imaging
More from this funder
Funder identifier:
http://dx.doi.org/10.13039/501100014748
Programme:
DPhil scholarship
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford

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