A cross-reactive tick cement antigen is a candidate broad-spectrum tick vaccine.

Journal article

Truncated constructs of 64P (64TRPs), a secreted cement protein from salivary glands of the tick Rhipicephalus appendiculatus, provided cross-protection against Rhipicephalus sanguineus and Ixodes ricinus, apparently by targeting antigens in the midgut and salivary glands of adults and nymphs, causing mortality. Tick feeding on 64TRP-immunised animals stimulated local inflammatory immune responses (involving basophils, eosinophils, lymphocytes, mast cells, macrophages and dendritic-like cells...

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Authors: Trimnell, A; Davies, G; Lissina, O; Hails, R; Nuttall, P

• Publication status: Published
• Journal: Vaccine
• Volume: 23
• Issue: 34
• Pages: 4329-4341
• Publication date: 2005-07-01
• DOI: 10.1016/j.vaccine.2005.03.041
• EISSN: 1873-2518
• ISSN: 0264-410X
• Language: English
• Keywords: Antigens; Cross Reactions; Cricetinae; Vaccines, Synthetic; Guinea Pigs; Tick Infestations; Animals; Immunization; Skin; Ticks