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Journal article

Lack of evidence for the efficacy of memantine in mild Alzheimer disease

Abstract:

Objective: We directly assessed the clinical trials' evidence for memantine's efficacy in mild Alzheimer disease (AD). Memantine is indicated in the United States and Europe for moderate to severe AD, which is diagnosed if a patient has a Mini-Mental State Examination (MMSE) score of less than 15 or less than 20, respectively. Yet memantine is very frequently prescribed for mild AD and mild cognitive impairment, and a manufacturer-sponsored meta-analysis claimed its efficacy in mild AD. Data ...

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Publisher copy:
10.1001/archneurol.2011.69

Authors


Schneider, LS More by this author
Dagerman, KS More by this author
Higgins, JPT More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, RDM, Stroke and Geratology
Journal:
Archives of Neurology
Volume:
68
Issue:
8
Pages:
991-998
Publication date:
2011-08-05
DOI:
EISSN:
1538-3687
ISSN:
0003-9942
URN:
uuid:9c5f4d7b-f42a-48ae-9a29-6ee06299beee
Source identifiers:
179213
Local pid:
pubs:179213
Language:
English

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