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Thesis

Rare genetic variants and susceptibility to severe bacterial diseases

Abstract:

Infectious diseases are a major cause of morbidity and mortality worldwide. Streptococcus pneumoniae

and Neisseria meningitidis are major causes of severe bacterial disease which can manifest as invasive disease such as bacteraemia and meningitis. Exposure to these pathogens is relatively widespread, yet only a minority of individuals develop invasive disease. A host genetic component to infectious disease susceptibility has been implied from twin and adoptee studies. A r... Expand abstract

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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Human Genetics Wt Centre
Role:
Author

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Role:
Supervisor
Role:
Supervisor
Medical Research Council More from this funder
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford
Language:
English
Keywords:
Subjects:
UUID:
uuid:9c5745f9-50f9-469a-8771-2e49e75db7ac
Deposit date:
2017-04-25

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