Journal article
Longitudinal changes in sputum and blood inflammatory mediators during FeNO suppression testing
- Abstract:
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To explore whether exhaled nitric oxide (FeNO) non-suppression identifies corticosteroid resistance, we analysed inflammatory mediator changes during a FeNO suppression test with monitored high-intensity corticosteroid therapy. In linear mixed-effects models analysed over time, the 15 clinically-distinct ‘suppressors’ (i.e. ≥42% FeNO suppression) normalised asthma control questionnaire scores (mean±SD: 2.8±1.4 to 1.4±0.9, p<0.0001) and sputum eosinophil counts (median [IQR]: 29 [6-41] to 1 [1...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Preview, Version of record, pdf, 2.2MB, Terms of use)
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- Publisher copy:
- 10.1136/thoraxjnl-2021-217994
Authors
Bibliographic Details
- Publisher:
- BMJ Publishing Group
- Journal:
- Thorax More from this journal
- Volume:
- 77
- Issue:
- 9
- Pages:
- 933-938
- Publication date:
- 2022-07-07
- Acceptance date:
- 2022-06-02
- DOI:
- EISSN:
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1468-3296
- ISSN:
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0040-6376
Item Description
- Language:
-
English
- Keywords:
- Pubs id:
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1261959
- Local pid:
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pubs:1261959
- Deposit date:
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2022-06-02
Terms of use
- Copyright holder:
- Couillard et al
- Copyright date:
- 2022
- Rights statement:
- © Author(s) (or their employer(s)) 2022. Re-use permitted under CC BY. Published by BMJ. This is an open access article distributed in accordance with the Creative Commons Attribution 4.0 Unported (CC BY 4.0) license, which permits others to copy, redistribute, remix, transform and build upon this work for any purpose, provided the original work is properly cited, a link to the licence is given, and indication of whether changes were made. See: https://creativecommons.org/licenses/by/4.0/.
- Licence:
- CC Attribution (CC BY)
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