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Journal article

Mechanisms for size-dependent protein segregation at immune synapses assessed with molecular rulers.

Abstract:

Immunological synapses are specialized intercellular contacts formed by several types of immune cells in contact with target cells or antigen-presenting cells. A late-stage immune synapse is commonly a bulls-eye pattern of immune cell receptor-ligand pairs surrounded by integrin complexes. Based on crystal structures, the intermembrane distance would be ∼15 nm for many immune cell receptor-ligand pairs, but ∼40 nm for integrin-ligand pairs. Close proximity of these two classes of intermembran...

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Publication status:
Published

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Publisher copy:
10.1016/j.bpj.2011.05.013

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Institution:
University of Oxford
Department:
Oxford, MSD, Biochemistry
Role:
Author
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Journal:
Biophysical journal
Volume:
100
Issue:
12
Pages:
2865-2874
Publication date:
2011-06-05
DOI:
EISSN:
1542-0086
ISSN:
0006-3495
URN:
uuid:9c464fb5-8617-447d-b8d1-54e2dfe21164
Source identifiers:
166528
Local pid:
pubs:166528

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