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5-hydroxymethylcytosine marks regions with reduced mutation frequency

Abstract:

CpG dinucleotides are the main mutational hot-spot in most cancers. The characteristic elevated C>T mutation rate in CpG sites has been related to 5-methylcytosine (5mC), an epigenetically modified base which resides in CpGs and plays a role in transcription silencing. In brain nearly a third of 5mCs have recently been found to exist in the form of 5-hydroxymethylcytosine (5hmC), yet the effect of 5hmC on mutational processes is still poorly understood. Here we show that 5hmC is associated...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted manuscript

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Publisher copy:
10.7554/eLife.17082

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Institution:
University of Oxford
Department:
Oxford, MSD, NDM, Oxford Ludwig Institute
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, NDM, Oxford Ludwig Institute
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, NDM, Oxford Ludwig Institute
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, NDM, NDM Experimental Medicine
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Funding agency for:
Schuster-Boeckler, PB
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Funding agency for:
Kriaucionis, S
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Funding agency for:
Tomkova, M
Publisher:
eLife Sciences Publications Publisher's website
Journal:
eLife Journal website
Publication date:
2016-05-05
DOI:
ISSN:
2050-084X
URN:
uuid:9c3a3f6b-b7fd-4845-9cf7-60de1a2bbd71
Source identifiers:
619463
Local pid:
pubs:619463

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