Journal article icon

Journal article

MDM2 SNP309 accelerates tumor formation in a gender-specific and hormone-dependent manner.

Abstract:

The importance of the p53 stress response pathway in the suppression of tumor formation is well documented. In a previous report, a single nucleotide polymorphism (SNP309 T/G) was found in the promoter of the MDM2 gene resulting in higher levels of MDM2 RNA and protein and, consequently, in the attenuation of the p53 pathway both in vitro and in vivo. As the SNP309 locus is found in a region of the MDM2 promoter, which is regulated by hormonal signaling pathways, and the G-allele of SNP309 in...

Expand abstract
Publication status:
Published

Actions


Access Document


Authors


Expand authors...
Journal:
Cancer research
Volume:
66
Issue:
10
Pages:
5104-5110
Publication date:
2006-05-05
DOI:
EISSN:
1538-7445
ISSN:
0008-5472
URN:
uuid:9c38fadc-63dc-4d83-a4d4-695240e97d87
Source identifiers:
69613
Local pid:
pubs:69613

Terms of use


Metrics


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP