The importance of the p53 stress response pathway in the suppression of tumor formation is well documented. In a previous report, a single nucleotide polymorphism (SNP309 T/G) was found in the promoter of the MDM2 gene resulting in higher levels of MDM2 RNA and protein and, consequently, in the attenuation of the p53 pathway both in vitro and in vivo. As the SNP309 locus is found in a region of the MDM2 promoter, which is regulated by hormonal signaling pathways, and the G-allele of SNP309 in...Expand abstract
- Publication status:
- Publisher copy:
- Copyright date:
MDM2 SNP309 accelerates tumor formation in a gender-specific and hormone-dependent manner.
Views and Downloads
If you are the owner of this record, you can report an update to it here: Report update to this record