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Thesis

Investigating molecular mechanisms of Dali, an intergenic chromatin-associated lincRNA regulating genes locally and neural differentiation genome-wide

Abstract:

Recently, long non-coding RNAs (lncRNAs) emerged as important regulators of many cellular functions. Many nuclear lncRNAs regulate the expression of geomically proximal or overlapping protein coding genes. Less clear is whether intergenic lncRNAs can regulate transcription by modulating chromatin at genomically distant loci in an RNA-dependent manner. This thesis investigated molecular functions of Dali, an intergenic central nervous system expressed lncRNA conserved in therian ma...

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Institution:
University of Oxford
Research group:
Ponting group
Oxford college:
St Cross College
Department:
Medical Sciences Division - Sherrington Building,Le Gros Clark Building
Role:
Author

Contributors

Role:
Supervisor
Role:
Supervisor
Publication date:
2014
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
Oxford University, UK
URN:
uuid:9c296666-927c-4c53-b250-39e79643b0f8
Local pid:
ora:9420

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