Journal article
Resistance of transmitted founder HIV-1 to IFITM-mediated restriction
- Abstract:
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Interferon-induced transmembrane proteins (IFITMs) restrict the entry of diverse enveloped viruses through incompletely understood mechanisms. While IFITMs are reported to inhibit HIV-1, their in vivo relevance is unclear. We show that IFITM sensitivity of HIV-1 strains is determined by the co-receptor usage of the viral envelope glycoproteins as well as IFITM subcellular localization within the target cell. Importantly, we find that transmitted founder HIV-1, which establishes de novo infect...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Preview, Version of record, pdf, 4.5MB, Terms of use)
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- Publisher copy:
- 10.1016/j.chom.2016.08.006
Authors
Funding
Bibliographic Details
- Publisher:
- Cell Press
- Journal:
- Cell Host and Microbe More from this journal
- Volume:
- 20
- Issue:
- 4
- Pages:
- 429–442
- Publication date:
- 2016-09-09
- Acceptance date:
- 2016-08-23
- DOI:
- EISSN:
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1934-6069
- ISSN:
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1931-3128
- Pmid:
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27640936
Item Description
- Language:
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English
- Keywords:
- Pubs id:
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pubs:645862
- UUID:
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uuid:9c28710c-004d-4aa5-b42e-598538960bcc
- Local pid:
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pubs:645862
- Source identifiers:
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645862
- Deposit date:
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2016-10-05
Terms of use
- Copyright holder:
- Foster et al
- Copyright date:
- 2016
- Notes:
- Copyright © 2016 The Author(s). Published by Elsevier Inc. Under a Creative Commons license.
- Licence:
- CC Attribution (CC BY)
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