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MicroRNA controlled adenovirus mediates anti-cancer efficacy without affecting endogenous microRNA activity.

Abstract:

MicroRNAs are small non-coding RNA molecules that regulate mRNA translation and stability by binding to complementary sequences usually within the 3' un-translated region (UTR). We have previously shown that the hepatic toxicity caused by wild-type Adenovirus 5 (Ad5WT) in mice can be prevented by incorporating 4 binding sites for the liver-specific microRNA, mir122, into the 3' UTR of E1A mRNA. This virus, termed Ad5mir122, is a promising virotherapy candidate and causes no obvious liver path...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1371/journal.pone.0016152

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Institution:
University of Oxford
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Institution:
University of Oxford
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Institution:
University of Oxford
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Institution:
University of Oxford
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Institution:
University of Oxford
Department:
Oxford, MSD, Oncology
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Funding agency for:
Cawood, R
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Funding agency for:
Seymour, LW
Cancer Research UK More from this funder
Medical Research Council More from this funder
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Publisher:
Public Library of Science Publisher's website
Journal:
PloS one Journal website
Volume:
6
Issue:
1
Pages:
e16152
Publication date:
2011
DOI:
EISSN:
1932-6203
ISSN:
1932-6203
URN:
uuid:9c2252ce-e3f2-403c-8de9-129f0976de5a
Source identifiers:
179126
Local pid:
pubs:179126

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