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Journal article

Switches and latches: a biochemical tug-of-war between the kinases and phosphatases that control mitosis.

Abstract:

Activation of the cyclin-dependent kinase (Cdk1) cyclin B (CycB) complex (Cdk1:CycB) in mitosis brings about a remarkable extent of protein phosphorylation. Cdk1:CycB activation is switch-like, controlled by two auto-amplification loops--Cdk1:CycB activates its activating phosphatase, Cdc25, and inhibits its inhibiting kinase, Wee1. Recent experimental evidence suggests that parallel to Cdk1:CycB activation during mitosis, there is inhibition of its counteracting phosphatase activity. We argu...

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Publication status:
Published

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Publisher copy:
10.1098/rstb.2011.0087

Authors


Domingo-Sananes, MR More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, Biochemistry
Journal:
Philosophical transactions of the Royal Society of London. Series B, Biological sciences
Volume:
366
Issue:
1584
Pages:
3584-3594
Publication date:
2011-12-05
DOI:
EISSN:
1471-2970
ISSN:
0962-8436
URN:
uuid:9c21b619-190f-4809-bf63-4c48aa71ffc4
Source identifiers:
206436
Local pid:
pubs:206436

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