Switches and latches: a biochemical tug-of-war between the kinases and phosphatases that control mitosis.

Journal article

Activation of the cyclin-dependent kinase (Cdk1) cyclin B (CycB) complex (Cdk1:CycB) in mitosis brings about a remarkable extent of protein phosphorylation. Cdk1:CycB activation is switch-like, controlled by two auto-amplification loops--Cdk1:CycB activates its activating phosphatase, Cdc25, and inhibits its inhibiting kinase, Wee1. Recent experimental evidence suggests that parallel to Cdk1:CycB activation during mitosis, there is inhibition of its counteracting phosphatase activity. We argu...

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Authors: Domingo-Sananes, MR; Kapuy, O; Hunt, T; Novak, B

• Publication status: Published
• Journal: Philosophical transactions of the Royal Society of London. Series B, Biological sciences
• Volume: 366
• Issue: 1584
• Pages: 3584-3594
• Publication date: 2011-12-01
• DOI: 10.1098/rstb.2011.0087
• EISSN: 1471-2970
• ISSN: 0962-8436
• Language: English
• Keywords: Fungal Proteins; CDC2 Protein Kinase; Yeasts; Interphase; Phosphorylation; Cell Cycle Checkpoints; Enzyme Activation; Mitosis; Cyclin B; cdc25 Phosphatases; Animals