Journal article icon

Journal article

Susceptibility of clinical isolates of Burkholderia pseudomallei to a lipid A biosynthesis inhibitor.

Abstract:

Burkholderia pseudomallei is the causative agent of melioidosis, a serious infection associated with high mortality and relapse. Current antimicrobial therapy using ceftazidime (CAZ) is often ineffective. Inhibitors of LpxC, the enzyme responsible for lipid A biosynthesis, have potential antimicrobial activity against several Gram-negative bacteria in vivo, but their activity against B. pseudomallei is unclear. Herein, we investigated the susceptibility of B. pseudomallei clinical isolates to...

Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

Actions


Access Document


Files:
Publisher copy:
10.4269/ajtmh.16-0858

Authors


Sengyee, S More by this author
Saiprom, N More by this author
Paksanont, S More by this author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM; Tropical Medicine
Wuthiekanun, V More by this author
Expand authors...
Mahidol University More from this funder
Royal Golden Jubilee PhD Programme More from this funder
Publisher:
American Society of Tropical Medicine and Hygiene Publisher's website
Journal:
American Journal of Tropical Medicine and Hygiene Journal website
Volume:
97
Issue:
1
Pages:
62-67
Publication date:
2017-07-05
Acceptance date:
2017-02-27
DOI:
EISSN:
1476-1645
ISSN:
0002-9637
Pubs id:
pubs:709472
URN:
uri:9c152574-7fc7-412b-ae1b-2c2e70835b7e
UUID:
uuid:9c152574-7fc7-412b-ae1b-2c2e70835b7e
Local pid:
pubs:709472

Terms of use


Metrics



If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP