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Journal article

Conserved TCR beta chain usage in reactive arthritis; evidence for selection by a putative HLA-B27-associated autoantigen.

Abstract:

Previous work suggested that expanded CD8+ T-cell clones in the synovial fluid (SF) of HLA-B27+ patients with reactive arthritis (ReA) preferentially use the T-cell receptor variable region (TCRBV) 1, similar CDR3 sequences, and joining region (BJ) 2S3. To determine the range of conservation and disease-specificity of CDR3-sequences, we analyzed the TCRBV1-J2S3 repertoire from 33 healthy HLA-B27+ individuals, patients with various types of spondyloarthropathies (SpA), and with rheumatoid arth...

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Publication status:
Published

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Authors


Frauendorf, E More by this author
Duchmann, R More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, NDORMS, Experimental Medicine Division
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Journal:
Tissue antigens
Volume:
60
Issue:
4
Pages:
299-308
Publication date:
2002-10-05
DOI:
EISSN:
1399-0039
ISSN:
0001-2815
URN:
uuid:9c13f5f5-0f72-448e-945d-b98e87fb2d10
Source identifiers:
32267
Local pid:
pubs:32267

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