- Abstract:
-
INTRODUCTION: IL-10 is an immunoregulatory cytokine which may modulate disease expression in rheumatoid arthritis (RA). The IL-10 gene is highly polymorphic with a number of single nucleotide polymorphisms in the promoter region and two microsatellite loci, IL10.R and IL10.G, 4 kb and 1.1 kb 5' of the transcription initiation site. It has been reported that allele 2 of the IL10.R microsatellite (IL10.R2) is associated with increased IL-10 secretion and IL10.R3 with reduced secretion. Subseque...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1093/rheumatology/keg054
-
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- Journal:
- Rheumatology (Oxford, England)
- Volume:
- 42
- Issue:
- 1
- Pages:
- 149-153
- Publication date:
- 2003-01-05
- DOI:
- EISSN:
-
1462-0332
- ISSN:
-
1462-0324
- URN:
-
uuid:9c0cf363-518c-4a26-8d5b-6e4d6ba2303e
- Source identifiers:
-
108525
- Local pid:
- pubs:108525
- Language:
- English
- Keywords:
- Copyright date:
- 2003
Journal article
Rheumatoid arthritis susceptibility and interleukin 10: a study of two ethnically diverse populations.
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