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Constitutive histamine H2 receptor activity regulates serotonin release in the substantia nigra.

Abstract:

The substantia nigra pars reticulata (SNr) forms a principal output from the basal ganglia. It also receives significant histamine (HA) input from the tuberomammillary nucleus whose functions in SNr remain poorly understood. One identified role is the regulation of serotonin (5-HT) neurotransmission via the HA-H(3) receptor. Here we have explored regulation by another HA receptor expressed in SNr, the H(2)-receptor (H(2)R), by monitoring electrically evoked 5-HT release with fast-scan cyclic ...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, Physiology Anatomy and Genetics
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Physiology Anatomy and Genetics
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Pharmacology
Journal:
Journal of neurochemistry
Volume:
107
Issue:
3
Pages:
745-755
Publication date:
2008-11-05
DOI:
EISSN:
1471-4159
ISSN:
0022-3042
URN:
uuid:9c0864f9-72d9-47c1-a619-a3b9ec6cf638
Source identifiers:
113831
Local pid:
pubs:113831

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