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EM visualization of transcription by RNA polymerase II: downstream termination requires a poly(A) signal but not transcript cleavage.

Abstract:

We have used EM visualization of active genes on plasmid vectors in Xenopus oocyte nuclei to investigate the relationship between poly(A) signals and RNA polymerase II transcription termination. Although a functional poly(A) signal is required for efficient termination, cotranscriptional RNA cleavage at the poly(A) site is not. Furthermore, the phenomena of termination and cotranscriptional RNA cleavage can be uncoupled, and the efficiency of both varies independently on different copies of t...

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Publication status:
Published

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Authors


Osheim, YN More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
Journal:
Molecular cell
Volume:
3
Issue:
3
Pages:
379-387
Publication date:
1999-03-05
DOI:
EISSN:
1097-4164
ISSN:
1097-2765
URN:
uuid:9bfba1d7-c220-410d-9ead-264602c622d1
Source identifiers:
27768
Local pid:
pubs:27768

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