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Sickle haemoglobin, haemoglobin C and malaria mortality feedbacks

Abstract:
Background: Sickle haemoglobin (HbS) and haemoglobin C (HbC) are both caused by point mutations in the beta globin gene, and both offer substantial malaria protection. Despite the fact that the blood disorder caused by homozygosity for HbC is much less severe than that caused by homozygosity for HbS (sickle cell anaemia), it is the sickle mutation which has come to dominate many old-world malarious regions, whilst HbC is highly restricted in its geographical distribution. It ... Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1186/s12936-015-1077-5

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Institution:
University of Oxford
Division:
MPLS
Department:
Zoology
Role:
Author
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Institution:
University of Oxford
Division:
MPLS
Department:
Zoology
Role:
Author
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Funding agency for:
Gupta, S
Grant:
Advanced investigator (DIVERSITY
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Funding agency for:
Gupta, S
Grant:
Advanced investigator (DIVERSITY
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Funding agency for:
Penman, B
Grant:
Junior Research Fellowship
More from this funder
Funding agency for:
Penman, B
Grant:
Junior Research Fellowship
Publisher:
BioMed Central Publisher's website
Journal:
Malaria Journal Journal website
Volume:
15
Article number:
16
Publication date:
2016-01-01
DOI:
ISSN:
1475-2875
Source identifiers:
581112
Keywords:
Pubs id:
pubs:581112
UUID:
uuid:9be58967-1ffc-41df-b733-f3cc480a9952
Local pid:
pubs:581112
Deposit date:
2016-01-06

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