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Sickle haemoglobin, haemoglobin C and malaria mortality feedbacks

Abstract:
Background: Sickle haemoglobin (HbS) and haemoglobin C (HbC) are both caused by point mutations in the beta globin gene, and both offer substantial malaria protection. Despite the fact that the blood disorder caused by homozygosity for HbC is much less severe than that caused by homozygosity for HbS (sickle cell anaemia), it is the sickle mutation which has come to dominate many old-world malarious regions, whilst HbC is highly restricted in its geographical distribution. It ... Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1186/s12936-015-1077-5

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Institution:
University of Oxford
Department:
Oxford, MPLS, Zoology
Role:
Author
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Institution:
University of Oxford
Department:
Oxford, MPLS, Zoology
Role:
Author
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Funding agency for:
Gupta, S
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Funding agency for:
Penman, BS
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Funding agency for:
Penman, BS
Publisher:
BioMed Central Publisher's website
Journal:
Malaria Journal Journal website
Volume:
15
Pages:
Article: 16
Publication date:
2016-01-01
DOI:
ISSN:
1475-2875
URN:
uuid:9be58967-1ffc-41df-b733-f3cc480a9952
Source identifiers:
581112
Local pid:
pubs:581112

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