- Abstract:
-
The MHC class II molecule DQ0602 confers strong susceptibility to narcolepsy but dominant protection against type 1 diabetes. The crystal structure of DQ0602 reveals the molecular features underlying these contrasting genetic properties. Structural comparisons to homologous DQ molecules with differential disease associations highlight a previously unrecognized interplay between the volume of the P6 pocket and the specificity of the P9 pocket, which implies that presentation of an expanded pep...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1073/pnas.0308458100
-
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- Journal:
- Proceedings of the National Academy of Sciences of the United States of America
- Volume:
- 101
- Issue:
- 7
- Pages:
- 1999-2004
- Publication date:
- 2004-02-05
- DOI:
- EISSN:
-
1091-6490
- ISSN:
-
0027-8424
- URN:
-
uuid:9ba79908-0ec3-4ca4-b7cf-d78a40735d21
- Source identifiers:
-
26684
- Local pid:
- pubs:26684
- Language:
- English
- Keywords:
- Copyright date:
- 2004
Journal article
Crystal structure of HLA-DQ0602 that protects against type 1 diabetes and confers strong susceptibility to narcolepsy.
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