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Crystal structure of HLA-DQ0602 that protects against type 1 diabetes and confers strong susceptibility to narcolepsy.

Abstract:

The MHC class II molecule DQ0602 confers strong susceptibility to narcolepsy but dominant protection against type 1 diabetes. The crystal structure of DQ0602 reveals the molecular features underlying these contrasting genetic properties. Structural comparisons to homologous DQ molecules with differential disease associations highlight a previously unrecognized interplay between the volume of the P6 pocket and the specificity of the P9 pocket, which implies that presentation of an expanded pep...

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Publication status:
Published

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Publisher copy:
10.1073/pnas.0308458100

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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Structural Biology
Role:
Author
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Journal:
Proceedings of the National Academy of Sciences of the United States of America
Volume:
101
Issue:
7
Pages:
1999-2004
Publication date:
2004-02-01
DOI:
EISSN:
1091-6490
ISSN:
0027-8424
Source identifiers:
26684

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