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Combination of vandetanib, radiotherapy, and irinotecan in the LoVo human colorectal cancer xenograft model.

Abstract:

PURPOSE: The tumor growth kinetics of the human LoVo colorectal xenograft model was assessed in response to vandetanib, an orally available receptor tyrosine kinase inhibitor, radiotherapy (RT), or irinotecan (CPT-11), as single therapies and in combination. METHODS AND MATERIALS: LoVo cells were injected subcutaneously into the right hind limb (5 x 10(6) cells in 100 microL phosphate-buffered saline) of athymic NCR NUM mice and tumors were grown to a volume of 200-300 mm(3) before treatment...

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Publication status:
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Authors


Wachsberger, P More by this author
Daskalakis, C More by this author
Dicker, AP More by this author
Journal:
International journal of radiation oncology, biology, physics
Volume:
75
Issue:
3
Pages:
854-861
Publication date:
2009-11-05
DOI:
EISSN:
1879-355X
ISSN:
0360-3016
URN:
uuid:9ba73b3f-2929-4173-87dc-31e434a1baae
Source identifiers:
315715
Local pid:
pubs:315715

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