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The role of inflammation in subventricular zone cancer

Abstract:

The adult subventricular zone (SVZ) stem cell niche has proven vital for discovering neurodevelopmental mechanisms and holds great potential in medicine for neurodegenerative diseases. Yet the SVZ holds a dark side - it can become tumorigenic. Glioblastomas can arise from the SVZ via cancer stem cells (CSCs). Glioblastoma and other brain cancers often have dismal prognoses since they are resistant to treatment. In this review we argue that the SVZ is susceptible to cancer because it contains ...

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Publication status:
Published
Peer review status:
Peer reviewed

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Authors


Bardella, C More by this author
Al-Shammari, AR More by this author
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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Physiology Anatomy and Genetics
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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
RDM; RDM Clinical Laboratory Sciences
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Oncology
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Publisher:
Elsevier Publisher's website
Journal:
Progress in Neurobiology Journal website
Publication date:
2018-04-11
Acceptance date:
2018-04-07
DOI:
EISSN:
1873-5118
ISSN:
0301-0082
Pubs id:
pubs:836606
URN:
uri:9ba58277-7fc7-4c1f-8e7b-349caf4a1201
UUID:
uuid:9ba58277-7fc7-4c1f-8e7b-349caf4a1201
Local pid:
pubs:836606
Language:
English
Keywords:

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