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Journal article

Impact of genetic manipulation on the fitness of Anopheles stephensi mosquitoes.

Abstract:

Genetic modification of mosquitoes offers exciting possibilities for controlling malaria, but success will depend on how transformation affects the fitness of modified insects. The expression of an exogenous gene, the mutations caused by its insertion, and inbreeding while transformed lines are established can all lead to reductions in fitness. Factors influencing fitness were investigated in cage experiments with four lines of transgenic Anopheles stephensi, a vector species of human malaria...

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Publication status:
Published

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Publisher copy:
10.1126/science.1081453

Authors


Catteruccia, F More by this author
Godfray, HC More by this author
Crisanti, A More by this author
Journal:
Science (New York, N.Y.)
Volume:
299
Issue:
5610
Pages:
1225-1227
Publication date:
2003-02-05
DOI:
EISSN:
1095-9203
ISSN:
0036-8075
URN:
uuid:9b9b474b-7df1-4dee-965f-a22f26db1024
Source identifiers:
210160
Local pid:
pubs:210160

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