- Abstract:
-
OBJECTIVE: There is a disparity in the animal models used to study pain in rheumatoid arthritis (RA), which tends to be acute in nature, and models used to assess the pathogenesis of RA. The latter models, like human RA, are lymphocyte-driven and polyarthritic. We assessed pain behavior and mechanisms in collagen-induced arthritis (CIA), the model of preclinical arthritis used most commonly in the field of immunology. We then validated the model using anti-tumor necrosis factor (anti-TNF) th...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1002/art.23063
-
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- Journal:
- Arthritis and rheumatism
- Volume:
- 56
- Issue:
- 12
- Pages:
- 4015-4023
- Publication date:
- 2007-12-05
- DOI:
- EISSN:
-
1529-0131
- ISSN:
-
0004-3591
- URN:
-
uuid:9b942f76-3b4d-4de8-a052-0912fd82e2b4
- Source identifiers:
-
224084
- Local pid:
- pubs:224084
- Copyright date:
- 2007
Journal article
Collagen-induced arthritis as a model of hyperalgesia: functional and cellular analysis of the analgesic actions of tumor necrosis factor blockade.
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