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Collagen-induced arthritis as a model of hyperalgesia: functional and cellular analysis of the analgesic actions of tumor necrosis factor blockade.

Abstract:

OBJECTIVE: There is a disparity in the animal models used to study pain in rheumatoid arthritis (RA), which tends to be acute in nature, and models used to assess the pathogenesis of RA. The latter models, like human RA, are lymphocyte-driven and polyarthritic. We assessed pain behavior and mechanisms in collagen-induced arthritis (CIA), the model of preclinical arthritis used most commonly in the field of immunology. We then validated the model using anti-tumor necrosis factor (anti-TNF) th...

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Publication status:
Published

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Publisher copy:
10.1002/art.23063

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Institution:
University of Oxford
Department:
Oxford, MSD, NDORMS
Role:
Author
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Journal:
Arthritis and rheumatism
Volume:
56
Issue:
12
Pages:
4015-4023
Publication date:
2007-12-05
DOI:
EISSN:
1529-0131
ISSN:
0004-3591
URN:
uuid:9b942f76-3b4d-4de8-a052-0912fd82e2b4
Source identifiers:
224084
Local pid:
pubs:224084

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