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Thesis

Studies on ribosomal oxygenases

Abstract:

The 2OG oxygenases comprise a superfamily of ferrous iron dependent dioxygenases with multiple biological roles, including in hypoxia sensing, transcriptional control, and splicing control. It was recently proposed that 2OG oxygenases catalyse the hydroxylation of ribosomal proteins in prokaryotes (ycfD) and in humans (NO66 and MINA53), raising the possibility that 2OG oxygenases also control translation. The work described in this thesis concerned investigations on the biochemical and fun...

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Institution:
University of Oxford
Research group:
Prof. Christopher J. Schofield
Oxford college:
St Catherine's College
Department:
Mathematical,Physical & Life Sciences Division - Chemistry - Chemistry Research Laboratory
Role:
Author

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Role:
Supervisor
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Funding agency for:
Rok Sekirnik
Publication date:
2014
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
Oxford University, UK
URN:
uuid:9b8d30f1-7401-48f3-9e60-91d4e515272b
Local pid:
ora:9595

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