- Abstract:
-
The development of effective vaccines against difficult disease targets will require the identification of new subunit vaccination strategies that can induce and maintain effective immune responses in humans. Here we report on a phase 1a clinical trial using the AMA1 antigen from the blood-stage Plasmodium falciparum malaria parasite delivered either as recombinant protein formulated with Alhydrogel adjuvant with and without CPG 7909, or using recombinant vectored vaccines--chimpanzee adenovi...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1038/mt.2014.157
-
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- Publisher:
- Nature Publishing Group
- Journal:
- Molecular therapy : the journal of the American Society of Gene Therapy
- Volume:
- 22
- Issue:
- 12
- Pages:
- 2142-2154
- Publication date:
- 2014-12-05
- DOI:
- EISSN:
-
1525-0024
- ISSN:
-
1525-0016
- URN:
-
uuid:9b8ab0ec-376a-4055-afc2-7d3349e9401f
- Source identifiers:
-
482202
- Local pid:
- pubs:482202
- Language:
- English
- Copyright date:
- 2014
Journal article
Combining viral vectored and protein-in-adjuvant vaccines against the blood-stage malaria antigen AMA1: report on a phase 1a clinical trial.
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