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Combining viral vectored and protein-in-adjuvant vaccines against the blood-stage malaria antigen AMA1: report on a phase 1a clinical trial.

Abstract:

The development of effective vaccines against difficult disease targets will require the identification of new subunit vaccination strategies that can induce and maintain effective immune responses in humans. Here we report on a phase 1a clinical trial using the AMA1 antigen from the blood-stage Plasmodium falciparum malaria parasite delivered either as recombinant protein formulated with Alhydrogel adjuvant with and without CPG 7909, or using recombinant vectored vaccines--chimpanzee adenovi...

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Publication status:
Published

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Publisher copy:
10.1038/mt.2014.157

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Publisher:
Nature Publishing Group
Journal:
Molecular therapy : the journal of the American Society of Gene Therapy
Volume:
22
Issue:
12
Pages:
2142-2154
Publication date:
2014-12-05
DOI:
EISSN:
1525-0024
ISSN:
1525-0016
URN:
uuid:9b8ab0ec-376a-4055-afc2-7d3349e9401f
Source identifiers:
482202
Local pid:
pubs:482202
Language:
English

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