Excitation-contraction (EC) coupling is the process by which Ca2+ is released from the sarcoplasmic reticulum (SR) and is fundamental to cardiac and skeletal muscle function. The SR contains many uncharacterised ion channels and proteins which may influence EC coupling and in this thesis I have investigated the biophysical properties of some of these channels.
I have demonstrated that the single-channel gating and conducting properties of SR K+ channels from va...Expand abstract
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- University of Oxford
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Characterisation of novel cardiac and skeletal ion channels on intracellular Ca2+ stores.
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