Journal article icon

Journal article

Secreted Gaussia luciferase as a sensitive reporter gene for in vivo and ex vivo studies of airway gene transfer.

Abstract:

The cationic lipid GL67A is one of the more efficient non-viral gene transfer agents (GTAs) for the lungs, and is currently being evaluated in an extensive clinical trial programme for cystic fibrosis gene therapy. Despite conferring significant expression of vector-specific mRNA following transfection of differentiated human airway cells cultured on air liquid interfaces (ALI) cultures and nebulisation into sheep lung in vivo we were unable to detect robust levels of the standard reporter ge...

Expand abstract
Publication status:
Published

Actions


Access Document


Authors


Griesenbach, U More by this author
Vicente, CC More by this author
Roberts, MJ More by this author
Expand authors...
Journal:
Biomaterials
Volume:
32
Issue:
10
Pages:
2614-2624
Publication date:
2011-04-05
DOI:
EISSN:
1878-5905
ISSN:
0142-9612
URN:
uuid:9b7ea647-5970-48bd-af2c-cc20db16bf8b
Source identifiers:
124550
Local pid:
pubs:124550

Terms of use


Metrics



If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP