Controlling the heart via the brain: a potential new therapy for orthostatic hypotension.

Journal article

OBJECTIVE: Electrical stimulation of the midbrain is known to influence blood pressure in animals. In humans, it is used for the treatment of chronic neuropathic pain. Our aim was to assess whether orthostatic hypotension can be successfully treated with deep brain stimulation of the periventricular/periaqueductal gray areas in humans. METHODS: We recruited 11 patients who had chronic neuropathic pain and who had undergone implantation of a deep brain stimulator in the periventricular/periaq...

Expand abstract

Authors: Green, A; Wang, S; Owen, S; Paterson, D; Stein, J

• Publication status: Published
• Journal: Neurosurgery
• Volume: 58
• Issue: 6
• Pages: 1176-1183
• Publication date: 2006-06-01
• DOI: 10.1227/01.neu.0000215943.78685.01
• EISSN: 1524-4040
• ISSN: 0148-396X
• Language: English
• Keywords: Humans; Chronic Disease; Middle Aged; Treatment Outcome; Female; Male; Neuralgia; Baroreflex; Case-Control Studies; Deep Brain Stimulation; Hypotension, Orthostatic; Cerebral Ventricles; Brain; Blood Pressure; Heart Rate; Adult; Aged; Periaqueductal Gray