Journal article icon

Journal article

Exosomes for targeted siRNA delivery across biological barriers

Abstract:

Using oligonucleotide-based drugs to modulate gene expression has opened a new avenue for drug discovery. In particular small interfering RNAs (siRNAs) are being rapidly recognized as promising therapeutic tools, but their poor bioavailability limits the full realization of their clinical potential. In recent years, cumulating evidence has emerged for the role of membrane vesicles, secreted by most cells and found in all body fluids, as key mediators of information transmission between cells....

Expand abstract

Actions


Access Document


Publisher copy:
10.1016/j.addr.2012.08.008

Authors


More by this author
Institution:
University of Oxford
Department:
Oxford
More by this author
Institution:
University of Oxford
Department:
Oxford
Journal:
Advanced Drug Delivery Reviews
Volume:
65
Issue:
3
Pages:
391-397
Publication date:
2013-03-01
DOI:
EISSN:
1872-8294
ISSN:
0169-409X
URN:
uuid:9b71e9d9-f117-433e-87bc-b495d414c680
Source identifiers:
394188
Local pid:
pubs:394188

Terms of use


Metrics



If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP