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Journal article

The structure of an interdomain complex that regulates talin activity.

Abstract:

Talin is a large flexible rod-shaped protein that activates the integrin family of cell adhesion molecules and couples them to cytoskeletal actin. It exists in both globular and extended conformations, and an intramolecular interaction between the N-terminal F3 FERM subdomain and the C-terminal part of the talin rod contributes to an autoinhibited form of the molecule. Here, we report the solution structure of the primary F3 binding domain within the C-terminal region of the talin rod and use...

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Publication status:
Published

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Publisher copy:
10.1074/jbc.m900078200

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Journal:
The Journal of biological chemistry
Volume:
284
Issue:
22
Pages:
15097-15106
Publication date:
2009-05-05
DOI:
EISSN:
1083-351X
ISSN:
0021-9258
URN:
uuid:9b6ebc85-1477-4be6-9431-f40911f1bbaf
Source identifiers:
218706
Local pid:
pubs:218706

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