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Thesis

Functional characterisation of multiple sclerosis-­associated single nucleotide polymorphisms in the Eomesodermin region

Abstract:

Multiple sclerosis (MS) is a common inflammatory neurological disease affecting young adults, causing significant disability and increased mortality. Genome wide association studies (GWAS) have uncovered over 100 single nucleotide polymorphisms (SNPs) associated with MS susceptibility, most of which lie outside transcribed DNA and therefore do not have obvious consequences. SNPs in two such non-coding DNA segments upstream of the EOMES gene, encoding Eomesodermin (Eomes) have been...

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Division:
MSD
Department:
Clinical Neurosciences
Role:
Author

Contributors

Department:
Nuffield department of clinical neurosciences
Role:
Supervisor
More from this funder
Funding agency for:
Leach, O
Grant:
947
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford
Language:
English
Keywords:
Subjects:
UUID:
uuid:9b6bc711-181a-41ab-ae41-8dfb31878f77
Deposit date:
2017-01-25

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