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Journal article

Severe disease expression of cardiac troponin C and T mutations in patients with idiopathic dilated cardiomyopathy.

Abstract:

OBJECTIVES: We performed genetic investigations of cardiac troponin T (TNNT2) and troponin C (TNNC1) in 235 consecutive patients with idiopathic dilated cardiomyopathy (DCM) to evaluate prevalence of mutations and associated disease expression in affected families. BACKGROUND: Recently, mutations in sarcomeric genes have been reported in DCM. However, the prevalence, penetrance, and clinical significance of sarcomere gene mutations in large consecutive cohorts of DCM patients are poorly defi...

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Publication status:
Published

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Publisher copy:
10.1016/j.jacc.2004.08.027

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Journal:
Journal of the American College of Cardiology
Volume:
44
Issue:
10
Pages:
2033-2040
Publication date:
2004-11-05
DOI:
EISSN:
1558-3597
ISSN:
0735-1097
URN:
uuid:9b65e0a8-adc7-40aa-89af-edcd18f770d6
Source identifiers:
104269
Local pid:
pubs:104269

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