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How transcriptional and epigenetic programmes are played out on an individual mammalian gene cluster during lineage commitment and differentiation.

Abstract:

In the post-genomic era, a great deal of work has focused on understanding how DNA sequence is used to programme complex nuclear, cellular and tissue functions throughout differentiation and development. There are many approaches to these issues, but we have concentrated on understanding how a single mammalian gene cluster is activated or silenced as stem cells undergo lineage commitment, differentiation and maturation. In particular we have analysed the alpha globin cluster, which is express...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, RDM, Molecular Medicine, Biomedical Research Centre
Vernimmen, D More by this author
De Gobbi, M More by this author
Anguita, E More by this author
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Journal:
Biochemical Society symposium
Volume:
73
Issue:
73
Pages:
11-22
Publication date:
2006
EISSN:
1744-1439
ISSN:
0067-8694
URN:
uuid:9b52bfd6-cf3d-4308-9fbf-28d4e3d60be8
Source identifiers:
56129
Local pid:
pubs:56129

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