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A neurotrophic mechanism directs sensory nerve transit in cranial bone

Abstract:

The flat bones of the skull are densely innervated during development, but little is known regarding their role during repair. We describe a neurotrophic mechanism that directs sensory nerve transit in the mouse calvaria. Patent cranial suture mesenchyme represents an NGF (nerve growth factor)-rich domain, in which sensory nerves transit. Experimental calvarial injury upregulates Ngf in an IL-1β/TNF-α-rich defect niche, with consequent axonal ingrowth. In calvarial osteoblasts, IL-1β and TNF-...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher:
Elsevier Publisher's website
Journal:
Cell Reports Journal website
Volume:
31
Issue:
8
Article number:
107696
Publication date:
2020-05-26
Acceptance date:
2020-05-06
DOI:
EISSN:
2211-1247
Pmid:
32460020
Pubs id:
1107288
Local pid:
pubs:1107288
Language:
English
Keywords:
Format:
Print

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