The flat bones of the skull are densely innervated during development, but little is known regarding their role during repair. We describe a neurotrophic mechanism that directs sensory nerve transit in the mouse calvaria. Patent cranial suture mesenchyme represents an NGF (nerve growth factor)-rich domain, in which sensory nerves transit. Experimental calvarial injury upregulates Ngf in an IL-1β/TNF-α-rich defect niche, with consequent axonal ingrowth. In calvarial osteoblasts, IL-1β and TNF-...Expand abstract
- Publication status:
- Peer review status:
- Peer reviewed
- Copyright holder:
- Meyers et al.
- Copyright date:
- Rights statement:
- Copyright © 2020 The Author(s). This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
A neurotrophic mechanism directs sensory nerve transit in cranial bone
If you are the owner of this record, you can report an update to it here: Report update to this record