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Detection and characterization of autoantibodies against modified self-proteins in SLE sera after exposure to reactive oxygen and nitrogen species.

Abstract:

There are over 120 types of autoantibodies found in the blood of SLE patients against cellular and extracellular components in both their native and posttranslationally modified forms. In recent years, these autoantibodies have provoked interest as initiators of pathology and as biomarkers of disease activity. Often, the host antigens employed in lab-based and commercially developed immunoassays use non-human antigen or non-modified host antigen as a probe for autoantibodies. Here, we describ...

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Institution:
University of Oxford
Department:
Oxford, MSD, Physiology Anatomy and Genetics
Role:
Author
Publisher:
Humana Press Inc.
Journal:
Methods in molecular biology (Clifton, N.J.)
Volume:
1134
Pages:
163-171
Publication date:
2014-01-01
DOI:
EISSN:
1940-6029
ISSN:
1064-3745
URN:
uuid:9b43db3e-99e7-4e54-92f4-8b1311d14af2
Source identifiers:
449044
Local pid:
pubs:449044

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