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Identification of tuberculosis susceptibility genes with human macrophage gene expression profiles.

Abstract:

Although host genetics influences susceptibility to tuberculosis (TB), few genes determining disease outcome have been identified. We hypothesized that macrophages from individuals with different clinical manifestations of Mycobacterium tuberculosis (Mtb) infection would have distinct gene expression profiles and that polymorphisms in these genes may also be associated with susceptibility to TB. We measured gene expression levels of >38,500 genes from ex vivo Mtb-stimulated macrophages in ...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1371/journal.ppat.1000229

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Institution:
University of Oxford
Role:
Author
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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Tropical Medicine
Role:
Author
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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Tropical Medicine
Role:
Author
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Funding agency for:
Farrar, J
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Funding agency for:
Dunstan, S
Farrar, J
Publisher:
Public Library of Science Publisher's website
Journal:
PLoS Pathog Journal website
Volume:
4
Issue:
12
Article number:
e1000229
Publication date:
2008-12-01
DOI:
EISSN:
1553-7374
ISSN:
1553-7366
Source identifiers:
34507

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