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Synergistic neurochemical and behavioural effects of acute intrahippocampal injection of brain-derived neurotrophic factor and antidepressants in adult mice.

Abstract:

Preclinical data support the view that brain-derived neurotrophic factor (BDNF) and serotonergic systems regulate circuits involved in affective disorders. The present study examined neurochemical and behavioural consequences of an acute intrahippocampal injection of BDNF combined with an antidepressant by using in-vivo intracerebral microdialysis in the ventral hippocampus (vHi) in conscious mice and behavioural paradigms predictive of antidepressant and anxiolytic-like effects [the mouse fo...

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Publisher copy:
10.1017/s1461145709000017

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Institution:
University of Oxford
Department:
Oxford, MSD, Physiology Anatomy and Genetics
Reperant, C More by this author
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Journal:
The international journal of neuropsychopharmacology / official scientific journal of the Collegium Internationale Neuropsychopharmacologicum (CINP)
Volume:
12
Issue:
7
Pages:
905-915
Publication date:
2009-08-05
DOI:
EISSN:
1469-5111
ISSN:
1461-1457
URN:
uuid:9b41f6d7-0173-4330-93cf-1f14d5f99227
Source identifiers:
426704
Local pid:
pubs:426704

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