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Vaccine adjuvants CpG (oligodeoxynucleotides ODNs), MPL (3-O-deacylated monophosphoryl lipid A) and naloxone-enhanced Th1 immune response to the Plasmodium vivax recombinant thrombospondin-related adhesive protein (TRAP) in mice

Abstract:

Despite considerable efforts toward vaccine development over decades, there is no available effective vaccine against Plasmodium vivax. Thrombospondin-related adhesive protein of P. vivax (PvTRAP) is essential for sporozoite motility and invasions into mosquito’s salivary gland and vertebrate’s hepatocyte; hence, it is a promising target for pre-erythrocytic vaccine. In the current investigation, the role of antibodies and cellular immune responses induced by purified recombinant PvTRAP (rPvT...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted Manuscript

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Publisher copy:
10.1007/s00430-018-0545-2

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Role:
Author
ORCID:
0000-0003-0933-0981
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Publisher:
Springer Publisher's website
Journal:
Medical Microbiology and Immunology Journal website
Volume:
207
Issue:
5-6
Pages:
271-286
Publication date:
2018-06-09
Acceptance date:
2018-05-23
DOI:
EISSN:
1432-1831
ISSN:
0300-8584
Pubs id:
pubs:858988
URN:
uri:9b41058b-3363-424d-a29d-5dd6a802017d
UUID:
uuid:9b41058b-3363-424d-a29d-5dd6a802017d
Local pid:
pubs:858988
Language:
English
Keywords:

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