The NO pathway acts late during the fertilization response in sea urchin eggs.

Journal article

Both the inositol 1,4,5-trisphosphate (InsP(3)) and ryanodine receptor pathways contribute to the Ca(2+) transient at fertilization in sea urchin eggs. To date, the precise contribution of each pathway has been difficult to ascertain. Evidence has accumulated to suggest that the InsP(3) receptor pathway has a primary role in causing Ca(2+) release and egg activation. However, this was recently called into question by a report implicating NO as the primary egg activator. In the present study w...

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Authors: Leckie, C; Empson, R; Becchetti, A; Thomas, J; Galione, A

• Publication status: Published
• Journal: Journal of biological chemistry
• Volume: 278
• Issue: 14
• Pages: 12247-12254
• Publication date: 2003-04-01
• DOI: 10.1074/jbc.m210770200
• EISSN: 1083-351X
• ISSN: 0021-9258
• Language: English
• Keywords: Ryanodine Receptor Calcium Release Channel; Calcium Signaling; Cyclic ADP-Ribose; Ovum; Sea Urchins; Fluorescent Dyes; Calcium; Animals; Female; Fertilization; Cyclic GMP; Nitric Oxide