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Dynamic reconfiguration of hippocampal interneuron circuits during spatial learning.

Abstract:

In the hippocampus, cell assemblies forming mnemonic representations of space are thought to arise as a result of changes in functional connections of pyramidal cells. We have found that CA1 interneuron circuits are also reconfigured during goal-oriented spatial learning through modification of inputs from pyramidal cells. As learning progressed, new pyramidal assemblies expressed in theta cycles alternated with previously established ones, and eventually overtook them. The firing patterns of...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, Pharmacology
Role:
Author
Journal:
Neuron
Volume:
78
Issue:
1
Pages:
166-180
Publication date:
2013-04-05
DOI:
EISSN:
1097-4199
ISSN:
0896-6273
URN:
uuid:9b35175b-e59c-495c-a475-a60b70377480
Source identifiers:
383563
Local pid:
pubs:383563

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