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Mechanisms of disease: aquaporin-4 antibodies in neuromyelitis optica.

Abstract:

Neuromyelitis optica (NMO) is a rare CNS inflammatory disorder that predominantly affects the optic nerves and spinal cord. Recent serological findings strongly suggest that NMO is a distinct disease rather than a subtype of multiple sclerosis. In NMO, serum antibodies, collectively known as NMO-IgG, characteristically bind to cerebral microvessels, pia mater and Virchow-Robin spaces. The main target antigen for this immunoreactivity has been identified as aquaporin-4 (AQP4). The antibodies a...

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Publication status:
Published

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Publisher copy:
10.1038/ncpneuro0764

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Institution:
University of Oxford
Division:
MSD
Department:
Clinical Neurosciences
Role:
Author
Journal:
Nature clinical practice. Neurology
Volume:
4
Issue:
4
Pages:
202-214
Publication date:
2008-04-01
DOI:
EISSN:
1745-8358
ISSN:
1745-834X
Source identifiers:
241661
Language:
English
Keywords:
Pubs id:
pubs:241661
UUID:
uuid:9b350252-b4ca-476d-89f7-81618fcb094e
Local pid:
pubs:241661
Deposit date:
2012-12-19

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