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Mechanisms of disease: aquaporin-4 antibodies in neuromyelitis optica.

Abstract:

Neuromyelitis optica (NMO) is a rare CNS inflammatory disorder that predominantly affects the optic nerves and spinal cord. Recent serological findings strongly suggest that NMO is a distinct disease rather than a subtype of multiple sclerosis. In NMO, serum antibodies, collectively known as NMO-IgG, characteristically bind to cerebral microvessels, pia mater and Virchow-Robin spaces. The main target antigen for this immunoreactivity has been identified as aquaporin-4 (AQP4). The antibodies a...

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Publication status:
Published

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Publisher copy:
10.1038/ncpneuro0764

Authors


Franciotta, D More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Neuroscience
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Journal:
Nature clinical practice. Neurology
Volume:
4
Issue:
4
Pages:
202-214
Publication date:
2008-04-05
DOI:
EISSN:
1745-8358
ISSN:
1745-834X
URN:
uuid:9b350252-b4ca-476d-89f7-81618fcb094e
Source identifiers:
241661
Local pid:
pubs:241661

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