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Evidence for a negative Pasteur effect in articular cartilage.

Abstract:

Uptake of external glucose and production of lactate were measured in freshly-excised bovine articular cartilage under O2 concentrations ranging from 21% (air) to zero (N2-bubbled). Anoxia (O2 concentration < 1% in the gas phase) severely inhibited both glucose uptake and lactate production. The decrease in lactate formation correlated closely with the decrease in glucose uptake, in a mole ratio of 2:1. This reduction in the rate of glycolysis in anoxic conditions is seen as evidence of a ...

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Publication status:
Published

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Journal:
The Biochemical journal
Volume:
321 ( Pt 1)
Issue:
1
Pages:
95-102
Publication date:
1997-01-05
EISSN:
1470-8728
ISSN:
0264-6021
URN:
uuid:9b3190fd-f974-48e2-88e7-e39d33aa53cb
Source identifiers:
433367
Local pid:
pubs:433367

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