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Minimal models for cell-cycle control based on competitive inhibition and multisite phosphorylations of Cdk substrates.

Abstract:

The eukaryotic cell cycle is characterized by alternating oscillations in the activities of cyclin-dependent kinase (Cdk) and the anaphase-promoting complex (APC). Successful completion of the cell cycle is dependent on the precise, temporally ordered appearance of these activities. A modest level of Cdk activity is sufficient to initiate DNA replication, but mitosis and APC activation require an elevated Cdk activity. In present-day eukaryotes, this temporal order is provided by a complex ne...

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Publication status:
Published

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Publisher copy:
10.1016/j.bpj.2013.02.012

Authors


Gérard, C More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, Biochemistry
Journal:
Biophysical journal
Volume:
104
Issue:
6
Pages:
1367-1379
Publication date:
2013-03-05
DOI:
EISSN:
1542-0086
ISSN:
0006-3495
URN:
uuid:9b2b125d-2436-4ca4-b4a4-75c767862584
Source identifiers:
390858
Local pid:
pubs:390858

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