Minimal models for cell-cycle control based on competitive inhibition and multisite phosphorylations of Cdk substrates.
The eukaryotic cell cycle is characterized by alternating oscillations in the activities of cyclin-dependent kinase (Cdk) and the anaphase-promoting complex (APC). Successful completion of the cell cycle is dependent on the precise, temporally ordered appearance of these activities. A modest level of Cdk activity is sufficient to initiate DNA replication, but mitosis and APC activation require an elevated Cdk activity. In present-day eukaryotes, this temporal order is provided by a complex ne...Expand abstract
- Publication status:
- Publisher copy:
- Copyright date: