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Small GTPases and LFA-1 reciprocally modulate adhesion and signaling.

Abstract:

Leukocyte-function-associated antigen-1 (LFA-1) is an integrin that is critical for T-cell adhesion and immunologic responses. As a transmembrane receptor and adhesion molecule, LFA-1 signals bidirectionally, whereby information about extracellular ligands is passed outside-in while cellular activation is transmitted inside-out to the adhesive ectodomain. Here, we review the role of small guanosine triphosphatases (GTPases) in LFA-1 signaling. Rap1, a Ras-related GTPase, appears to be central...

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Institution:
University of Oxford
Department:
Oxford, MSD, NDORMS
Role:
Author
Journal:
Immunological reviews
Volume:
218
Issue:
1
Pages:
114-125
Publication date:
2007-08-05
DOI:
EISSN:
1600-065X
ISSN:
0105-2896
URN:
uuid:9b23535c-ed4d-445a-aa0d-776e1bc964e9
Source identifiers:
482595
Local pid:
pubs:482595

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