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The role of specialized transcription factories in chromosome pairing.

Abstract:

Homologous chromosomes can pair in somatic and germ line cells, and many mechanisms have been proposed to explain how they do so. One popular class of models involves base-pairing between DNA strands catalyzed by recombination proteins, but pairing still occurs in mutants lacking the relevant functional proteins. We discuss an alternative based on two observations: transcription occurs in factories that specialize in transcribing specific gene sub-sets, and chromosomes only pair when transcri...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
Journal:
Biochimica et biophysica acta
Volume:
1783
Issue:
11
Pages:
2155-2160
Publication date:
2008-11-05
DOI:
ISSN:
0006-3002
URN:
uuid:9b1788a3-d5f9-48e6-9749-733d9562691e
Source identifiers:
15878
Local pid:
pubs:15878

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